Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin.

@article{Coen1983MutationsIT,
  title={Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin.},
  author={Donald M Coen and Phillip A. Furman and D P Aschman and Priscilla A. Schaffer},
  journal={Nucleic acids research},
  year={1983},
  volume={11 15},
  pages={5287-97}
}
Fourteen mutants known or likely to contain mutations in the herpes simplex virus DNA polymerase gene were examined for their sensitivity to aphidicolin in plaque reduction assays. Eleven of these exhibited some degree of hypersensitivity to the drug; altered aphidicolin-sensitivity correlated with altered sensitivity to the pyrophosphate analog… CONTINUE READING