Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A.

@article{Liu2009MutationsIT,
  title={Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A.},
  author={Zhe Liu and John M Robida and Sreedhar Chinnaswamy and Guanghui Yi and Jason M. Robotham and Heather B. Nelson and Andr{\'e} Southernman Teixeira Irsigler and Cheng Kao and Hengli Tang},
  journal={Hepatology},
  year={2009},
  volume={50 1},
  pages={25-33}
}
UNLABELLED Hepatitis C virus (HCV) infection leads to acute and chronic liver diseases, and new classes of anti-HCV therapeutics are needed. Cyclosporine A (CsA) inhibits HCV replication and CsA derivatives that lack the immunosuppressive function are currently in clinical trials as candidate anti-HCV drugs. Here we characterize several independently derived HCV replicons with varying levels of CsA resistance due to mutations in nonstructural protein 5B (NS5B), the HCV-encoded polymerase… CONTINUE READING
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Characterization of mechanism of resistance to cyclophilin inhibitors in HCV replicon

  • B Wiedmann, X Puyang, D Poulin, JE Mathy, S Ma, LJ Anderson
  • International Symposium on Hepatitis C Virus and…
  • 2008

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