Mutations in the glucokinase gene of the fetus result in reduced birth weight

@article{Hattersley1998MutationsIT,
  title={Mutations in the glucokinase gene of the fetus result in reduced birth weight},
  author={Andrew T Hattersley and Frances Beards and Elizabeth Ballantyne and Maggie Appleton and Rod Harvey and Sian Ellard},
  journal={Nature Genetics},
  year={1998},
  volume={19},
  pages={268-270}
}
Low birth weight and fetal thinness have been associated with non-insulin dependent diabetes mellitus (NIDDM) and insulin resistance in childhood and adulthood. It has been proposed that this association results from fetal programming in response to the intrauterine environment. An alternative explanation is that the same genetic influences alter both intrauterine growth and adult glucose tolerance. Fetal insulin secretion in response to maternal glycaemia plays a key role in fetal growth, and… CONTINUE READING
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