Mutations in the gene encoding the 34 kDa subunit of yeast replication protein A cause defective S phase progression.

@article{Santocanale1995MutationsIT,
  title={Mutations in the gene encoding the 34 kDa subunit of yeast replication protein A cause defective S phase progression.},
  author={C Santocanale and H Neecke and Maria Pia Longhese and G. Lucchini and Paolo Plevani},
  journal={Journal of molecular biology},
  year={1995},
  volume={254 4},
  pages={
          595-607
        }
}
The in vivo function of the 34 kDa subunit of yeast replication protein A (RPA), encoded by the RFA2 gene, has been studied by analyzing the effect of Rpa34 depletion and by producing and characterizing rfa2 temperature-sensitive mutants. We show that unbalanced stoichiometry of the RPA subunits does not affect cell growth and cell cycle progression until the level of Rpa34 becomes rate-limiting, at which point cells arrest with a late S/G2 DNA content. Rpa34 is involved in DNA replication in… CONTINUE READING

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