Mutations in the filaggrin gene in Han Chinese patients with atopic dermatitis.

@article{Zhang2011MutationsIT,
  title={Mutations in the filaggrin gene in Han Chinese patients with atopic dermatitis.},
  author={H Zhang and Yifeng Guo and Weiwei Wang and Mei Shi and Xilan Chen and Zhirong Yao},
  journal={Allergy},
  year={2011},
  volume={66 3},
  pages={420-7}
}
BACKGROUND Recently, loss-of-function mutations in the filaggrin gene (FLG) have been identified as the cause of ichthyosis vulgaris (IV) and also predisposing factors for atopic dermatitis (AD) and AD-associated phenotypes. Until now, over thirty mutations in FLG have been identified in patients with IV and AD, but the FLG mutation spectrum is not clear for Chinese Han patients with AD. This study aimed to investigate the role of FLG mutations in AD and AD-associated phenotypes in a Chinese… CONTINUE READING
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