Mutations in the double-stranded RNA-activated protein kinase insert region that uncouple catalysis from eIF2alpha binding.

Abstract

The interferon-induced, double-stranded RNA (dsRNA)-activated protein kinase, PKR, inhibits protein synthesis via phosphorylation of the alpha subunit of the translation initiation factor eIF2. A kinase insert region N-terminal of PKR kinase subdomain V, which is conserved among eIF2alpha kinases, has been proposed to determine substrate specificity of… (More)

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