Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.

@article{Saatcioglu1997MutationsIT,
  title={Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.},
  author={Fahri Saatcioglu and Gladys E. Lopez and Brian L West and Ebrahim Zandi and Weijun Feng and Huiling Lu and Ali Esmaili and James W. Apriletti and Peter J. Kushner and J. D. Baxter and Michael Karin},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 8},
  pages={4687-95}
}
A short C-terminal sequence that is deleted in the v-ErbA oncoprotein and conserved in members of the nuclear receptor superfamily is required for normal biological function of its normal cellular counterpart, the thyroid hormone receptor alpha (T3R alpha). We carried out an extensive mutational analysis of this region based on the crystal structure of the hormone-bound ligand binding domain of T3R alpha. Mutagenesis of Leu398 or Glu401, which are surface exposed according to the crystal… CONTINUE READING

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