Mutations in the connexin26/GJB2 gene are the most common event in non-syndromic hearing loss among the German population.

@article{Gabriel2001MutationsIT,
  title={Mutations in the connexin26/GJB2 gene are the most common event in non-syndromic hearing loss among the German population.},
  author={H D Gabriel and Petra Kupsch and J Sudendey and Elke Winterhager and Klaus Jahnke and Juergen Lautermann},
  journal={Human mutation},
  year={2001},
  volume={17 6},
  pages={521-2}
}
Congenital sensorineural hearing loss affects approximately 1/1,000 live births. Mutations in the gene encoding connexin26 (GJB2) have been described as a major cause of genetic nonsyndromic hearing impairment. Additionally, another gap junction gene, connexin30 (GJB6), was found to be responsible for hereditary hearing loss. We have studied 134 patients with severe to profound hearing loss or deafness and 13 patients with mild to moderate nonsyndromic sensorineural hearing loss in order to… CONTINUE READING

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