Mutations in the cardiac transcription factor GATA4 in patients with lone atrial fibrillation.

@article{Posch2010MutationsIT,
  title={Mutations in the cardiac transcription factor GATA4 in patients with lone atrial fibrillation.},
  author={Maximilian G. Posch and L -H Boldt and Michael Polotzki and Silke Richter and Sascha Rolf and Andreas Perrot and Rainer Dietz and Cemil Ozcelik and Wilhelm Haverkamp},
  journal={European journal of medical genetics},
  year={2010},
  volume={53 4},
  pages={201-3}
}
Familial recurrence of atrial fibrillation (AF) is reported in up to 15% of patients with lone AF. Recently, it was proposed that congenital defects in the morphogenesis of the pulmonary vein myocardium are involved in genetic pathogenesis of lone AF. GATA4 is a cardiac transcription factor essentially involved in myocardial development. Mutations in GATA4 are associated with congenital cardiac malformations. To investigate whether GATA4 mutations represent a genetic origin for AF the coding… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…