Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase 1 DNA damage response axis in colon cancers.

@article{Lewis2007MutationsIT,
  title={Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase 1 DNA damage response axis in colon cancers.},
  author={Kriste A. Lewis and Jamie N. Bakkum-Gamez and Ralitsa Loewen and Amy J. French and Stephen N. Thibodeau and William A. Cliby},
  journal={Genes, chromosomes & cancer},
  year={2007},
  volume={46 12},
  pages={1061-8}
}
In response to certain types of DNA damage, ataxia telangiectasia and rad3-related (ATR) phosphorylates checkpoint kinase 1 (CHEK1) resulting in cell cycle arrest and subsequent DNA repair. ATR and CHEK1 contain mononucleotide microsatellite repeat regions, which are mutational targets in tumors with defective mismatch repair (MMR). This study examined the frequency of such mutations in colon cancers and their impact on biologic behavior. Screening for ATR mutations in 48 tumors was performed… CONTINUE READING

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