Corpus ID: 18965736

Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.

@article{Tilley1996MutationsIT,
  title={Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.},
  author={W. Tilley and G. Buchanan and T. Hickey and J. Bentel},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1996},
  volume={2 2},
  pages={
          277-85
        }
}

• W. Tilley, G. Buchanan, +1 author J. Bentel
• Published 1996
• Biology, Medicine
• Clinical cancer research : an official journal of the American Association for Cancer Research

Progression to androgen-independent growth of human prostate cancers may be mediated by alterations in the structure and/or expression of the androgen receptor (AR) gene. To date, mutations in the AR gene have largely been identified in hormone refractory tumors. In this study, single-strand conformational polymorphism analysis and DNA sequencing of the entire AR gene coding region was performed on 25 primary prostate tumors sampled prior to initiation of hormonal (i.e. , androgen ablation… Expand

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