Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.
@article{Tilley1996MutationsIT, title={Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.}, author={W. Tilley and G. Buchanan and T. Hickey and J. Bentel}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={1996}, volume={2 2}, pages={ 277-85 } }
Progression to androgen-independent growth of human prostate cancers may be mediated by alterations in the structure and/or expression of the androgen receptor (AR) gene. To date, mutations in the AR gene have largely been identified in hormone refractory tumors. In this study, single-strand conformational polymorphism analysis and DNA sequencing of the entire AR gene coding region was performed on 25 primary prostate tumors sampled prior to initiation of hormonal (i.e. , androgen ablation… Expand
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