Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.

@article{Tilley1996MutationsIT,
  title={Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.},
  author={Wayne D Tilley and Grant Buchanan and Theresa E Hickey and Jacqueline M Bentel},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1996},
  volume={2 2},
  pages={277-85}
}
Progression to androgen-independent growth of human prostate cancers may be mediated by alterations in the structure and/or expression of the androgen receptor (AR) gene. To date, mutations in the AR gene have largely been identified in hormone refractory tumors. In this study, single-strand conformational polymorphism analysis and DNA sequencing of the entire AR gene coding region was performed on 25 primary prostate tumors sampled prior to initiation of hormonal (i.e. , androgen ablation… CONTINUE READING

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Identification of two transcription activation units in the N-terminal domain of the human androgen receptor

  • G. Jenster, Vanderkorput, M H.A.G., J. Trapman, A. O. Brinkmann
  • J. Biol. Chem.,
  • 1995
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