Mutations in the TAR hairpin affect the equilibrium between alternative conformations of the HIV-1 leader RNA.

@article{Huthoff2001MutationsIT,
  title={Mutations in the TAR hairpin affect the equilibrium between alternative conformations of the HIV-1 leader RNA.},
  author={Hendrik Huthoff and Ben Berkhout},
  journal={Nucleic acids research},
  year={2001},
  volume={29 12},
  pages={2594-600}
}
The HIV-1 untranslated leader RNA can adopt two mutually exclusive conformations that represent alternative secondary structures. This leader RNA can fold either an extended duplex through long-distance base pairing or a branched conformation in which the RNA locally folds into hairpin structures. Both leader RNA conformations have the TAR hairpin in common, which forms the extreme 5' end of all HIV-1 transcripts. We report that truncation of the TAR hairpin shifts the equilibrium between the… CONTINUE READING

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