Mutations in the S4 Region Isolate the Final Voltage-dependent Cooperative Step in Potassium Channel Activation

Abstract

Charged residues in the S4 transmembrane segment play a key role in determining the sensitivity of voltage-gated ion channels to changes in voltage across the cell membrane. However, cooperative interactions between subunits also affect the voltage dependence of channel opening, and these interactions can be altered by making substitutions at uncharged… (More)

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@article{Ledwell1999MutationsIT, title={Mutations in the S4 Region Isolate the Final Voltage-dependent Cooperative Step in Potassium Channel Activation }, author={Jennifer L. Ledwell and Richard W. Aldrich}, journal={The Journal of General Physiology}, year={1999}, volume={113}, pages={389 - 414} }