Mutations in the S gene region of hepatitis B virus genotype D in Golestan Province-Iran

  title={Mutations in the S gene region of hepatitis B virus genotype D in Golestan Province-Iran},
  author={Abdolvahab Moradi and Sareh Zhand and Amir Ghaemi and Naeme Javid and Alijan Tabarraei},
  journal={Virus Genes},
Mutations of HBsAg especially within the “a” determinant could alter the antigenicity of the protein causing failure of HBsAg neutralization and escaping from the host’s immune system, resulting in active viral replication and liver disease. This project aimed to investigate mutation in the S gene region of HBV infected patients in Golestan Province-Iran. HBV-DNA extractions from plasma and PCR of 100 patients were performed. Direct sequencing and alignment of S gene were applied using… CONTINUE READING


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