Mutations in the Rho Transcription Termination Factor That Affect RNA Tracking*

@article{Xu2002MutationsIT,
  title={Mutations in the Rho Transcription Termination Factor That Affect RNA Tracking*},
  author={Yi Xu and Harold L Kohn and William Widger},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={30023 - 30030}
}
Model studies have identified 16 conserved positively charged amino acids that form a positive strip pointing toward the center hole of Rho. Fourteen residues were individually changed to either an alanine or a glycine and one to a glutamate. Residues Arg269, Arg272, Lys283, Arg296, Lys298, and Arg299 form a subdomain (locus) located N-terminal to (above) the ATP hydrolysis domain (P-loop) and mutations in these residues led to either inactive Rho or to proteins displaying decreasedk cat for… 

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