Mutations in the Parkinson's disease genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA), are not associated with essential tremor.

@article{Clark2010MutationsIT,
  title={Mutations in the Parkinson's disease genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA), are not associated with essential tremor.},
  author={Lorraine N. Clark and Sergey Kisselev and Naeun Park and Barbara Ross and Miguel Verbitsky and Eileen Rios and Roy N Alcalay and Joseph H Lee and Elan Daniel Louis},
  journal={Parkinsonism & related disorders},
  year={2010},
  volume={16 2},
  pages={132-5}
}
We evaluated an association between essential tremor (ET) and the Parkinson's disease (PD) genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA). Clinical studies demonstrate an association between ET and PD, suggesting possible shared pathophysiologies, yet LRRK2 has rarely been studied in ET, and GBA, not at all. ET cases (n = 275, including 42 with rest tremor) and controls (n = 289) were enrolled in an epidemiological study (Columbia University). Post-mortem brain tissue… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 14 references

Glucocerebrosidase mutations are associated with Dementia with Lewy bodies

  • LN Clark, LA Kartsaklis, RW Gilbert, B Dorado, BM Ross, S Kisselev
  • Arch Neurol
  • 2009
2 Excerpts

Essential tremor and the common LRRK 2 G 2385 R variant

  • EK Tan, J Lee, Lim H-Q, Y Yuen, Y Zhao
  • Parkinsonism Relat Disord
  • 2008

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