Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapy.

@article{Hamano2005MutationsIT,
  title={Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapy.},
  author={Kosei Hamano and Naoya Sakamoto and Nobuyuki Enomoto and Namiki Izumi and Yasuhiro Asahina and Masayuki Kurosaki and Eri Ueda and Yoko Tanabe and Shinya Maekawa and Jun Itakura and Hideki Watanabe and Sei Kakinuma and Mamoru Watanabe},
  journal={Journal of gastroenterology and hepatology},
  year={2005},
  volume={20 9},
  pages={1401-9}
}
BACKGROUND AND AIM Combination treatments of interferon-alpha (IFN) and ribavirin (RBV) are more effective than those of IFN alone in hepatitis C virus (HCV) infection. However, mechanisms of the action of the combination regimen are not well understood. To elucidate the viral genetic basis of IFN plus RBV combination therapy, genetic variabilities of HCV-1b were analyzed. METHODS We performed pair-wise comparisons of full-length HCV genomic sequences in three patients' sera before and after… CONTINUE READING

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