Mutations in the NS5A and E2-PePHD regions of hepatitis C virus genotype 1b and response to combination therapy of interferon plus ribavirin.

@article{Yang2003MutationsIT,
  title={Mutations in the NS5A and E2-PePHD regions of hepatitis C virus genotype 1b and response to combination therapy of interferon plus ribavirin.},
  author={S S Yang and M W-Y Lai and D. -S. Chen and G Chen and Jia-Horng Kao},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2003},
  volume={23 6},
  pages={426-33}
}
BACKGROUND/AIMS Combination therapy with interferon (IFN) and ribavirin is the current standard treatment for chronic hepatitis C, but the efficacy is still not satisfactory, especially for genotype 1b. NS5A and E2 proteins of hepatitis C virus (HCV) may repress the IFN-induced RNA-dependent protein kinase (PKR), and thus have the potential to influence the response of HCV to IFN therapy; however, this issue remains controversial. METHODS Nucleotide sequences of the PKR-eIF2alpha… CONTINUE READING
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