Mutations in the NF-κB signaling pathway: implications for human disease

@article{Courtois2006MutationsIT,
  title={Mutations in the NF-κB signaling pathway: implications for human disease},
  author={Gilles Courtois and Thomas D. Gilmore},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={6831-6843}
}
The nuclear factor-kappa B (NF-κB) signaling pathway is a multi-component pathway that regulates the expression of hundreds of genes that are involved in diverse and key cellular and organismal processes, including cell proliferation, cell survival, the cellular stress response, innate immunity and inflammation. Not surprisingly, mis-regulation of the NF-κB pathway, either by mutation or epigenetic mechanisms, is involved in many human and animal diseases, especially ones associated with… CONTINUE READING