Mutations in the Caenorhabditis elegans Serotonin Reuptake Transporter MOD-5 Reveal Serotonin-Dependent and -Independent Activities of Fluoxetine

@article{Ranganathan2001MutationsIT,
  title={Mutations in the Caenorhabditis elegans Serotonin Reuptake Transporter MOD-5 Reveal Serotonin-Dependent and -Independent Activities of Fluoxetine},
  author={Rajesh Ranganathan and Elizabeth R. Sawin and Carol Trent and H. Robert Horvitz},
  journal={The Journal of Neuroscience},
  year={2001},
  volume={21},
  pages={5871 - 5884}
}
We isolated two mutants defective in the uptake of exogenous serotonin (5-HT) into the neurosecretory motor neurons ofCaenorhabditis elegans. These mutants were hypersensitive to exogenous 5-HT and hyper-responsive in the experience-dependent enhanced slowing response to food modulated by 5-HT. The two allelic mutations defined the gene mod-5(modulation of locomotion defective), which encodes the only serotonin reuptake transporter (SERT) in C. elegans. The selective serotonin reuptake… 

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