Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein.

@article{Cleves1991MutationsIT,
  title={Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein.},
  author={Ann E. Cleves and Todd P. McGee and E A Whitters and Kathleen M Champion and Jacqueline R. Aitken and William Dowhan and Mark Goebl and Vytas A Bankaitis},
  journal={Cell},
  year={1991},
  volume={64 4},
  pages={789-800}
}
SEC14p is the yeast phosphatidylinositol (PI)/phosphatidylcholine (PC) transfer protein, and it effects an essential stimulation of yeast Golgi secretory function. We now report that the SEC14p localizes to the yeast Golgi and that the SEC14p requirement can be specifically and efficiently bypassed by mutations in any one of at least six genes. One of these suppressor genes was the structural gene for yeast choline kinase (CKI), disruption of which rendered the cell independent of the normally… CONTINUE READING