Mutations in the C-terminus of the conserved NDR kinase, Cbk1p of Saccharomyces cerevisiae, make the protein independent of upstream activators

@article{Panozzo2009MutationsIT,
  title={Mutations in the C-terminus of the conserved NDR kinase, Cbk1p of Saccharomyces cerevisiae, make the protein independent of upstream activators},
  author={Cristina Panozzo and Myriam Bourens and Aleksandra Nowacka and Christopher J. Herbert},
  journal={Molecular Genetics and Genomics},
  year={2009},
  volume={283},
  pages={111-122}
}
In Saccharomyces cerevisiae, the RAM network is involved in cell separation after cytokinesis, cell integrity and cell polarity. The key function of this network is the regulation of the activity of the protein kinase Cbk1p, which is a member of the conserved NDR kinase family. Cbk1p function is controlled by its sub-cellular localization and at least two phosphorylation events: an auto phosphorylation in the kinase domain (S570) and the phosphorylation of a C-terminal hydrophobic motif by an… CONTINUE READING

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Molecular cloning: a laboratory manual, 2nd edn

  • J Sambrook, EF Fritsch, T Maniatis
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