Mutations in the 5' trailer region of a respiratory syncytial virus minigenome which limit RNA replication to one step.

@article{Peeples2000MutationsIT,
  title={Mutations in the 5' trailer region of a respiratory syncytial virus minigenome which limit RNA replication to one step.},
  author={Mark E Peeples and Peter L. Collins},
  journal={Journal of virology},
  year={2000},
  volume={74 1},
  pages={146-55}
}
The 3' termini of the genomic and antigenomic RNAs of human respiratory syncytial virus (RSV) are identical at 10 of the first 11 nucleotide positions and 21 of the first 26 positions. These conserved 3'-terminal sequences are thought to contain the genomic and antigenomic promoters. Furthermore, the complement of each conserved sequence (i.e., the 5' end of the RNA it encodes) might contain an encapsidation signal. Using an RSV minigenome system, we individually mutated each of the last seven… CONTINUE READING
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