Mutations in the 23S rRNA gene are associated with clarithromycin resistance in Helicobacter pylori isolates in Brazil

@article{Ribeiro2003MutationsIT,
  title={Mutations in the 23S rRNA gene are associated with clarithromycin resistance in Helicobacter pylori isolates in Brazil},
  author={Marcelo Lima Ribeiro and Lea Vitiello and Maira de Carvalho Bueno Miranda and Yune Helena Borges Benvengo and Anita Paula Ortiz Godoy and Sergio Mendonça and Jos{\'e} Pedrazzoli},
  journal={Annals of Clinical Microbiology and Antimicrobials},
  year={2003},
  volume={2},
  pages={11 - 11}
}
Resistance of Helicobacter pylori to clarithromycin has been associated with A2142G and A2143G point mutations in the 23S rRNA gene. Thus, the purpose of the present study was to determine the prevalence of each mutation in 52 clarithromycin-resistant H. pylori strains and to characterize the influence each type of mutation on the MIC. The MIC for clarithromycin was determined by the agar dilution method, and the point mutations of H. pylori were detected by PCR followed by restriction fragment… CONTINUE READING