Mutations in the β-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brain

@article{Arama2000MutationsIT,
  title={Mutations in the β-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brain},
  author={Eli Arama and Dalia Dickman and Ziva Kimchie and Allen Shearn and Zeev Lev},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={3706-3716}
}
Inactivation of both alleles of the fruit fly D. melanogaster brain tumor (brat) gene results in the production of a tumor-like neoplasm in the larval brain, and lethality in the larval third instar and pupal stages. We cloned the brat gene from a transposon-tagged allele and identified its gene product. brat encodes for an 1037 amino acid protein with an N-terminal B-box1 zinc finger followed by a B-box2 zinc finger, a coiled-coil domain, and a C-terminal β-propeller domain with six blades… CONTINUE READING
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