Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis.

@article{Drenth2002MutationsIS,
  title={Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis.},
  author={Joost P. H. Drenth and Rene te Morsche and Jan B. M. J. Jansen},
  journal={Gut},
  year={2002},
  volume={50 5},
  pages={687-92}
}
BACKGROUND Although chronic pancreatitis is associated with risk factors such as alcoholism, hyperparathyroidism, and hypertriglyceridaemia, little is known of the actual aetiology of the disease. It is thought that inappropriate activation of trypsinogen causes pancreatitis, and indeed in cases of hereditary pancreatitis mutations of cationic trypsinogen… CONTINUE READING