Mutations in proteins of the alternative pathway of complement and the pathogenesis of atypical hemolytic uremic syndrome.

@article{AbarrateguiGarrido2008MutationsIP,
  title={Mutations in proteins of the alternative pathway of complement and the pathogenesis of atypical hemolytic uremic syndrome.},
  author={Cynthia Abarrategui-Garrido and Marta Melgosa and Antonia Pe{\~n}a-Carri{\'o}n and Elena Goicoechea de Jorge and Santiago Rodr{\'i}guez de C{\'o}rdoba and Margarita L{\'o}pez-Trascasa and Pilar S{\'a}nchez-Corral},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2008},
  volume={52 1},
  pages={171-80}
}
Atypical hemolytic uremic syndrome is associated with mutations in the complement proteins factor H, factor I, factor B, C3, or membrane cofactor protein in about 50% of patients. The evolution and prognosis of the disease in patients carrying mutations in factor H is particularly poor, and renal transplantation most often fails because of recurrence of the… CONTINUE READING