Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection.

@article{Murakami1999MutationsIN,
  title={Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection.},
  author={Tadashi Murakami and Nobuyuki Enomoto and Masayuki Kurosaki and Namiki Izumi and Fumiaki Marumo and Chifumi Sato},
  journal={Hepatology},
  year={1999},
  volume={30 4},
  pages={1045-53}
}
An association has been reported between mutations in the amino acid residues 2209-2248 of the nonstructural protein 5A (NS5A) gene (interferon-sensitivity determining region [ISDR]) and interferon efficacy in hepatitis C virus (HCV)-1b infection. This relationship was analyzed in chronic HCV-2 infection. Forty patients with HCV-2a and 35 with HCV-2b were treated with interferon alfa for 6 months with a total dose of 468 to 860 million units. Pretreatment NS5A sequences were determined by… CONTINUE READING

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