Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity

  title={Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity},
  author={I. Farooqi and S. O'Rahilly},
  journal={Nature Clinical Practice Endocrinology &Metabolism},
  • I. Farooqi, S. O'Rahilly
  • Published 2008
  • Medicine
  • Nature Clinical Practice Endocrinology &Metabolism
  • Obesity is associated with increased morbidity and mortality from cardiovascular disease, diabetes mellitus and certain cancers. The prevalence of obesity is increasing rapidly throughout the world and is now recognized as a major global public-health concern. Although the increased prevalence of obesity is undoubtedly driven by environmental factors, the evidence that inherited factors profoundly influence human fat mass is equally compelling. Twin and adoption studies indicate that up to 70… CONTINUE READING
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