Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function.

@article{Bentham2013MutationsIH,
  title={Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function.},
  author={Matthew J. Bentham and Toshana L. Foster and Christopher A McCormick and Stephen Griffin},
  journal={The Journal of general virology},
  year={2013},
  volume={94 Pt 10},
  pages={2236-48}
}
Hepatitis C virus (HCV) p7 protein is critical for the efficient production of infectious virions in culture. p7 undergoes genotype-specific protein-protein interactions as well as displaying channel-forming activity, making it unclear whether the phenotypes of deleterious p7 mutations result from the disruption of one or both of these functions. Here, we showed that proton channel activity alone, provided in trans by either influenza virus M2 or genotype 1b HCV p7, was both necessary and… CONTINUE READING
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