Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro.

Abstract

To determine whether adefovir is active against lamivudine-resistant hepatitis B virus (HBV), the inhibition constants of adefovir diphosphate and lamivudine triphosphate for wild-type and mutant human HBV DNA polymerases, which contain amino acid substitutions associated with lamivudine resistance, were compared. Recombinant wild-type and mutant human HBV… (More)

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@article{Xiong1998MutationsIH, title={Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro.}, author={X R Xiong and Cesar Mateo Flores and Henry C. Yang and John Jay Toole and Craig S Gibbs}, journal={Hepatology}, year={1998}, volume={28 6}, pages={1669-73} }