Mutations in half baked/E-cadherin block cell behaviors that are necessary for teleost epiboly.

@article{Kane2005MutationsIH,
  title={Mutations in half baked/E-cadherin block cell behaviors that are necessary for teleost epiboly.},
  author={Donald A. Kane and Karen N McFarland and Rachel M. Warga},
  journal={Development},
  year={2005},
  volume={132 5},
  pages={1105-16}
}
Epiboly, the spreading of the blastoderm over the large yolk cell, is the first morphogenetic movement of the teleost embryo. Examining this movement as a paradigm of vertebrate morphogenesis, we have focused on the epiboly arrest mutant half baked (hab), which segregates as a recessive lethal, including alleles expressing zygotic-maternal dominant (ZMD) effects. Here we show that hab is a mutation in the zebrafish homolog of the adhesion protein E-cadherin. Whereas exclusively recessive… CONTINUE READING
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