Mutations in exon 14 of dihydropyrimidine dehydrogenase and 5-Fluorouracil toxicity in Portuguese colorectal cancer patients

Abstract

Purpose: Dihydropyrimidine dehydrogenase is a critical enzyme in the catabolism of 5-Fluorouracil, a drug frequently used in cancer therapy. Patients with deficient dihydropyrimidine dehydrogenase activity are at risk of developing severe 5-Fluorouracil–associated toxicity. Genetic analysis of the gene coding for dihydropyrimidine dehydrogenase has shown… (More)
DOI: 10.1097/01.GIM.0000118061.66602.A5

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