Mutations in dihydropteroate synthase gene of Pneumocystis carinii in HIV patients with Pneumocystis carinii pneumonia.

@article{Visconti2001MutationsID,
  title={Mutations in dihydropteroate synthase gene of Pneumocystis carinii in HIV patients with Pneumocystis carinii pneumonia.},
  author={Elena Visconti and Elena Ortona and Paola Mencarini and Paola Margutti and Salvatore Marinaci and Maria Zolfo and Alessandra Siracusano and Enrica Tamburrini},
  journal={International journal of antimicrobial agents},
  year={2001},
  volume={18 6},
  pages={547-51}
}
The purpose of this study was to determine whether dihydropteroate synthase gene (DHPS) mutations were associated with the failure of sulpha/sulphone drugs used as prophylaxis agents in HIV infected patients. Results suggested that DHPS mutations were significantly associated with failure of anti-Pneumocystis carinii sulphone prophylaxis (P=0.031). An increasing number of mutant P. carinii strains have been isolated from patients no longer having prophylaxis. There was no statistically… CONTINUE READING