Mutations in ccf, a novel Drosophila gene encoding a chromosomal factor, affect progression through mitosis and interact with Pc-G mutations.

@article{Kodjabachian1998MutationsIC,
  title={Mutations in ccf, a novel Drosophila gene encoding a chromosomal factor, affect progression through mitosis and interact with Pc-G mutations.},
  author={Laurent Kodjabachian and Mich{\`e}le Delaage and Christophe Maurel and R. Miassod and Bernard Jacq and Roland Rosset},
  journal={The EMBO journal},
  year={1998},
  volume={17 4},
  pages={1063-75}
}
We report herein the isolation of ccf, a new gene located in region 82E and essential for Drosophila development. This gene, expressed throughout development, encodes a novel product of 68 kDa which is found in the nucleus during interphase and labels, in a novel pattern, centrosomes and chromosome arms during mitosis. Mutations in ccf give rise to late larvae with small imaginal discs and to adults showing appendages of reduced size, consistent with CCF involvement in cell proliferation… CONTINUE READING
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