Mutations in ap1b1 Cause Mistargeting of the Na+/K+-ATPase Pump in Sensory Hair Cells

@inproceedings{Grisham2013MutationsIA,
  title={Mutations in ap1b1 Cause Mistargeting of the Na+/K+-ATPase Pump in Sensory Hair Cells},
  author={Rachel Clemens Grisham and Katie S Kindt and Karin C. Finger-Baier and Bettina Schmid and Teresa Nicolson},
  booktitle={PloS one},
  year={2013}
}
The hair cells of the inner ear are polarized epithelial cells with a specialized structure at the apical surface, the mechanosensitive hair bundle. Mechanotransduction occurs within the hair bundle, whereas synaptic transmission takes place at the basolateral membrane. The molecular basis of the development and maintenance of the apical and basal compartments in sensory hair cells is poorly understood. Here we describe auditory/vestibular mutants isolated from forward genetic screens in… CONTINUE READING