Mutations in a putative agonist binding region of the AMPA-selective glutamate receptor channel.

@article{Uchino1992MutationsIA,
  title={Mutations in a putative agonist binding region of the AMPA-selective glutamate receptor channel.},
  author={Shigeo Uchino and Kenji Sakimura and Kenji Nagahari and Masayoshi Mishina},
  journal={FEBS letters},
  year={1992},
  volume={308 3},
  pages={253-7}
}
The region preceding putative transmembrane segment M1 of the glutamate receptor (GluR) channel is well conserved among subunits and has been proposed to constitute a part of the agonist binding site. The functional significance of this region was examined by introducing point mutations into charged residues of the alpha 1 subunit of the mouse alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective GluR channel. The dose-response relationships of the mutant receptors were… CONTINUE READING

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