Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

@article{Rost2004MutationsIV,
  title={Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2},
  author={Simone Rost and Andreas Fregin and V Iva{\vs}kevi{\vc}ius and Ernst Conzelmann and Konstanze H{\"o}rtnagel and H. J. Pelz and Knut Tore Lappeg{\aa}rd and Erhard Seifried and Inge Scharrer and Edward G. D. Tuddenham and Clemens R. Müller and Tim Matthias Strom and Johannes Oldenburg},
  journal={Nature},
  year={2004},
  volume={427},
  pages={537-541}
}
Coumarin derivatives such as warfarin represent the therapy of choice for the long-term treatment and prevention of thromboembolic events. Coumarins target blood coagulation by inhibiting the vitamin K epoxide reductase multiprotein complex (VKOR). This complex recycles vitamin K 2,3-epoxide to vitamin K hydroquinone, a cofactor that is essential for the post-translational γ-carboxylation of several blood coagulation factors. Despite extensive efforts, the components of the VKOR complex have… 
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TLDR
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TLDR
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  • Biology, Medicine
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  • 2008
TLDR
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TLDR
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TLDR
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