Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.

@article{Pesiridis2009MutationsIT,
  title={Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.},
  author={G. Scott Pesiridis and Virginia M-Y Lee and John Q. Trojanowski},
  journal={Human molecular genetics},
  year={2009},
  volume={18 R2},
  pages={R156-62}
}
Amyotrophic lateral sclerosis (ALS) is the most common adult motor neuron disease that affects approximately 2/100,000 individuals each year worldwide. Patients with ALS suffer from rapidly progressive degeneration of motor neurons ultimately leading to death. The major pathological features observed in post-mortem tissue from patients with ALS are motor neuron loss, cortical spinal tract degeneration, gliosis and cytoplasmic neuronal inclusions formed by TDP-43 or TAR DNA binding Protein with… CONTINUE READING
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