Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

@article{Mombaerts1992MutationsIT,
  title={Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages},
  author={Peter Mombaerts and Alan R. Clarke and Michael Rudnicki and John Iacomini and Shigeyoshi Itohara and Juan J Lafaille and Lili Wang and Yoshiaki Ichikawa and Rudolf Jaenisch and Martin Hooper and Susumu Tonegawa},
  journal={Nature},
  year={1992},
  volume={360},
  pages={225-231}
}
Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8− thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-α is irrelevant in these developmental processes. The development of γδ T cells does not depend on either TCR-α or TCP-β. 
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