Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions

@article{Kunst1997MutationsIS,
  title={Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions},
  author={Catherine B. Kunst and {\'E}va Mezey and Michael J. Brownstein and David Patterson},
  journal={Nature Genetics},
  year={1997},
  volume={15},
  pages={91-94}
}
A subset of familial and sporadic amyotrophic lateral sclerosis (ALS — a fatal disorder characterised by progressive motor neuron degeneration) cases are due to mutations in the gene encoding Cu,Zn superoxide dismutase (SOD1)1–4. Two mutations which have been successfully used to generate transgenic mice that develop an ALS-like syndrome are glycine 85 to… CONTINUE READING