Mutations in RNA splicing machinery in human cancers.

  title={Mutations in RNA splicing machinery in human cancers.},
  author={Benjamin L. Ebert and Olivier Adrien Bernard},
  journal={The New England journal of medicine},
  volume={365 26},
Massively parallel sequencing of cancer genomes is revealing a panoramic view of the genetic drivers of human neoplasms. In this issue of the Journal, Wang et al.1 describe an analysis of the coding sequences of samples from 91 patients with chronic lymphocytic leukemia. The disease is characterized by the accumulation of mature B lymphocytes, and its genetic basis is being rapidly elucidated.2,3 Wang et al. leveraged the large number of samples studied to identify sets of genes that are… CONTINUE READING


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