Mutations in RAD3, MSH2, and RAD52 affect the rate of gene amplification in the yeast Saccharomyces cerevisiae.

@article{Peterson2000MutationsIR,
  title={Mutations in RAD3, MSH2, and RAD52 affect the rate of gene amplification in the yeast Saccharomyces cerevisiae.},
  author={Carolyn L. Peterson and Jennifer Joy Kordich and Laura Milligan and Elek Bodor and Angela Siner and K{\'a}lm{\'a}n Nagy and Charlotte E. Paquin},
  journal={Environmental and molecular mutagenesis},
  year={2000},
  volume={36 4},
  pages={
          325-34
        }
}
We report here the use of the ADH4:CUP1 amplification detection system to identify five high amplification rate (HAR) strains of Saccharomyces cerevisiae that display 40- to 600-fold higher amplification rates than those of parental strains. We have identified a mutation in RAD3 DNA repair helicase gene in HAR strain B9-40 that results in a 40-fold increase in amplification rate. RAD3 is the functional homolog of the human XPD gene, suggesting that this model system will provide important… CONTINUE READING
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