Mutations in PI3K/AKT pathway genes and amplifications of PIK3CA are associated with patterns of recurrence in gastric cancers.

@article{Fang2016MutationsIP,
  title={Mutations in PI3K/AKT pathway genes and amplifications of PIK3CA are associated with patterns of recurrence in gastric cancers.},
  author={Wen-Liang Fang and Kuo-Hung Huang and Yuan-Tzu Lan and Chien-hsing Lin and Shih-Ching Chang and M H Chen and Yee Chao and Wen-chang Lin and Su-Shun Lo and Anna Fen-yau Li and C W Wu and Shih-Hwa Chiou and Yi-Ming Shyr},
  journal={Oncotarget},
  year={2016},
  volume={7 5},
  pages={6201-20}
}
Mutations in genes involved in the PI3K/AKT pathway and amplifications of the PIK3CA gene in gastric cancer and their associations with clinicopathological characteristics and EBV infection were analyzed in this study. A total of 431 patients with gastric adenocarcinomas were enrolled, and 39 mutation hotspots were evaluated in these patients using MALDI-TOF mass spectrometry were analyzed. PIK3CA amplifications were analyzed using real-time quantitative PCR. Regarding patients with intestinal… CONTINUE READING