Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness

@article{BechHansen2000MutationsIN,
  title={Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness},
  author={N. Torben Bech-Hansen and M. J. Naylor and Tracy A. Maybaum and Rebecca L. Sparkes and Ben F. Koop and David G. Birch and Arthur A. B. Bergen and Clemens F.M. Prinsen and Robert C. Polomeno and Andreas Gal and Arlene V. Drack and Maria A. Musarella and Samuel G. Jacobson and Rockefeller S. L. Young and Richard G. Weleber},
  journal={Nature Genetics},
  year={2000},
  volume={26},
  pages={319-323}
}
During development, visual photoreceptors, bipolar cells and other neurons establish connections within the retina enabling the eye to process visual images over approximately 7 log units of illumination. Within the retina, cells that respond to light increment and light decrement are separated into ON- and OFF-pathways. Hereditary diseases are known to disturb these retinal pathways, causing either progressive degeneration or stationary deficits. Congenital stationary night blindness (CSNB) is… CONTINUE READING
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