Mutations in NEXN, a Z-disc gene, are associated with hypertrophic cardiomyopathy.

@article{Wang2010MutationsIN,
  title={Mutations in NEXN, a Z-disc gene, are associated with hypertrophic cardiomyopathy.},
  author={Hu Wang and Zhaohui Li and Jizheng Wang and Kai Sun and Qiqiong Cui and Lei Song and Yubao Zou and Xiaojian Wang and Xuan Liu and Rutai Hui and Yuxin Fan},
  journal={American journal of human genetics},
  year={2010},
  volume={87 5},
  pages={687-93}
}
Hypertrophic cardiomyopathy (HCM), the most common inherited cardiac disorder, is characterized by increased ventricular wall thickness that cannot be explained by underlying conditions, cadiomyocyte hypertrophy and disarray, and increased myocardial fibrosis. In as many as 50% of HCM cases, the genetic cause remains unknown, suggesting that more genes may be involved. Nexilin, encoded by NEXN, is a cardiac Z-disc protein recently identified as a crucial protein that functions to protect… CONTINUE READING