Mutations in LRRC50 Predispose Zebrafish and Humans to Seminomas

  title={Mutations in LRRC50 Predispose Zebrafish and Humans to Seminomas},
  author={Sander G. Basten and Erica E Davis and Ad J. M. Gillis and Ellen van Rooijen and Hans Stoop and Nikolina Babala and Ive Logister and Zachary Heath and Trudy G. N. Jonges and Nicholas Katsanis and Emile E Voest and Fredericus J. M. van Eeden and Ren{\'e} H Medema and Ren{\'e} F Ketting and Stefan Schulte-Merker and Leendert H. J. Looijenga and Rachel H Giles},
  booktitle={PLoS genetics},
Seminoma is a subclass of human testicular germ cell tumors (TGCT), the most frequently observed cancer in young men with a rising incidence. Here we describe the identification of a novel gene predisposing specifically to seminoma formation in a vertebrate model organism. Zebrafish carrying a heterozygous nonsense mutation in Leucine-Rich Repeat Containing protein 50 (lrrc50 also called dnaaf1), associated previously with ciliary function, are found to be highly susceptible to the formation of… CONTINUE READING
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