Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.

@article{Khelifa2014MutationsID,
  title={Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.},
  author={Mariem Ben Khelifa and Charles Coutton and Raoudha Zouari and Thomas Karaouzene and John Rendu and Marie Bidart and Sandra Yassine and Virginie J Pierre and Julie Delaroche and Sylviane Hennebicq and Didier Grunwald and Denise Escalier and Karine Pernet-Gallay and Pierre-Simon Jouk and Nicolas Thierry-Mieg and Aminata Tour{\'e} and Christophe Arnoult and Pierre F Ray},
  journal={American journal of human genetics},
  year={2014},
  volume={94 1},
  pages={95-104}
}
Ten to fifteen percent of couples are confronted with infertility and a male factor is involved in approximately half the cases. A genetic etiology is likely in most cases yet only few genes have been formally correlated with male infertility. Homozygosity mapping was carried out on a cohort of 20 North African individuals, including 18 index cases, presenting with primary infertility resulting from impaired sperm motility caused by a mosaic of multiple morphological abnormalities of the… CONTINUE READING
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