• DOI:10.1038/362059a0
Corpus ID: 265436

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

@article{Rosen1993MutationsIC,
  title={Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis},
  author={D. R. Rosen and T. Siddique and D. Patterson and D. Figlewicz and P. Sapp and A. Hentati and D. Donaldson and J. Goto and J. P. O'Regan and H. Deng and Z. Rahmani and A. Krizus and D. Mckenna-Yasek and A. Cayabyab and S. Gaston and R. Berger and R. Tanzi and J. Halperin and B. Herzfeldt and R. V. D. Bergh and W. Hung and T. Bird and Gang Deng and D. Mulder and C. Smyth and N. G. Laing and E. Soriano and M. Pericak-Vance and J. Haines and G. Rouleau and James S. Gusella and H. Horvitz and R. Brown},
  journal={Nature},
  year={1993},
  volume={362},
  pages={59-62}
}

D. R. Rosen, T. Siddique, +30 authors R. Brown

Published 1993

Biology, Medicine

Nature

AMYOTROPHIC lateral sclerosis (ALS) is a degenerative disorder of motor neurons in the cortex, brainstem and spinal cord1,2. Its cause is unknown and it is uniformly fatal, typically within five years3. About 10% of cases are inherited as an autosomal dominant trait, with high penetrance after the sixth decade4,5. In most instances, sporadic and autosomal dominant familial ALS (FALS) are clinically similar4,6,7. We have previously shown that in some but not all FALS pedigrees the disease is… CONTINUE READING

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