Mutations in Clotting Factors and Inflammatory Bowel Disease

  title={Mutations in Clotting Factors and Inflammatory Bowel Disease},
  author={Charles N. Bernstein and Michael Sargent and Hans L. Vos and Frits Richard Rosendaal},
  journal={The American Journal of Gastroenterology},
BACKGROUND:Patients with Crohn's disease (CD) and ulcerative colitis (UC) have a three- to fourfold greater risk of venous thrombosis compared with the general population. We aimed to determine if patients with CD and UC had a greater likelihood of mutations in genes that increase clotting risk, in a population-based case–control study.METHODS:Subjects were drawn from the University of Manitoba IBD Research Registry and controls were drawn from Manitoba Health's administrative database. Cases… 

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